![]() ![]() ![]() Rs4731532, rs3807306, rs11761199 and rs79288514 were associated with the incidence of micro/macro albuminuria. Rs4731532, rs3807306, and rs11761199 were associated with the incidence of CKD defined by the KDIGO. In the cross-sectional analysis, rs10954213 and rs10954214 were associated with eGFR and rs1874328 with urinary albumin/creatinine ratio (ACR). Data were analyzed for three endpoints during a 9-year follow-up, incidence of:at least stage 3 CKD, the KDIGO criterion “certain drop in eGFR”, and incidence of micro/macro albuminuria. ![]() Associations of SNPs with baseline renal parameters were assessed. cohort from the general population (n = 4820). We genotyped eleven IRF5 SNPs in the French D.E.S.I.R. We study whether allelic variations in IRF5 are associated with the incidence of chronic kidney disease (CKD) in a general population. GWAS have reported that the IRF5 locus is associated with autoimmune diseases and with the estimated glomerular filtration rate (eGFR). The Interferon Regulatory Factor (IRF)-5 is a key transcription factor in the pro-inflammatory polarization of M1-like macrophages. Inflammation has been associated with renal diseases. ![]()
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